High-dose, short-duration therapy with Acthar eliminates both spasms and hypsarrhythmia in cryptogenic and symptomatic cases of IS.1-3

Acthar is available as a 5-mL multidose vial containing 80 U/mL (400 U/5-mL vial) that requires no reconstitution or reformulation. Acthar should be dosed as recommended by the FDA: 75 U/m2 twice daily for 2 weeks with a gradual taper of an additional 2 weeks to avoid adrenal insufficiency.1

In the treatment of IS, Acthar is administered by intramuscular injection, which helps ensure IS patients are given the full and correct dose.

The dose of Acthar is typically calculated using the Mosteller formula for determining body surface area (BSA).22


Acthar should never be administered intravenously. Prolonged use of Acthar may produce cataracts, glaucoma, and secondary ocular infections. Monitor for signs and symptoms.

Step-by-step injection training guides

Available in English and Spanish for the parents and caregivers of infants with IS. See available Acthar resources.

Helpful Resources

Download the IS dosing app now

Have the IS Dosing Calculator app ready when you need it.

Physician Referral/Prescription Form

Download for your practice to complete.

Reimbursement and co-pay support

Helping you help children with IS get Acthar A.S.A.P.