Acthar Gel is a naturally sourced complex mixture of adrenocorticotropic hormone (ACTH) analogs and other pituitary peptides. A major component in the formulated complex mixture is N-25 deamidated porcine ACTH (1-39).1

Acthar Gel has been approved by the FDA for multiple conditions since 1952 and for IS since 2010.11

In clinical trials, Acthar Gel satisfied the American Academy of Neurology (AAN) and Child Neurology Society (CNS) guidelines on treating IS.2,5,12-14

Acthar Gel is contraindicated in patients with scleroderma, osteoporosis, systemic fungal infections, ocular herpes simplex, recent surgery, history of or the presence of a peptic ulcer, congestive heart failure, uncontrolled hypertension, primary adrenocortical insufficiency, adrenocortical hyperfunction, or sensitivity to proteins of porcine origins.

Appropriate patients for Acthar Gel

Under 2 years of age with any etiology of IS1-3:

  • Cryptogenic
  • Symptomatic, including tuberous sclerosis (TS)

Characterized by2,5,6:

  • Confirmed clusters of myoclonic or tonic seizures (spasms)
  • Hypsarrhythmia confirmed by EEG

In the treatment of IS, Acthar Gel is given as an injection into the muscle. Do not inject it under the skin, into a vein, or give it to a child by mouth. Administration of live or live attenuated vaccines is contraindicated in patients receiving immunosuppressive doses of Acthar Gel.

Helpful Resources

Step-by-Step Injection Training Guide

Download this convenient and easy-to-follow Injection Training Guide for caregivers of children with IS.

Acthar Referral Form

Download, complete, and fax the Referral Form to order Acthar Gel for your appropriate patients.

Take the guesswork out of dosing Acthar Gel for IS

From per-injection volume to number of vials, our calculator simplifies the process.