High-dose, short-duration therapy with Acthar Gel eliminates both spasms and hypsarrhythmia in cryptogenic and symptomatic cases of IS.1-3

Acthar Gel is available as a 5-mL multidose vial containing 80 U/mL (400 U/5-mL vial) that requires no reconstitution or reformulation. The recommended dose of Acthar Gel in the FDA-approved label is: 75 U/m2 twice daily for 2 weeks with a gradual taper of an additional 2 weeks to avoid adrenal insufficiency.1

In the treatment of IS, Acthar Gel is administered by intramuscular injection, which helps ensure IS patients are given the full and correct dose.

The dose of Acthar Gel is typically calculated using the Mosteller formula for determining body surface area (BSA).20


In the treatment of IS, Acthar Gel is given as an injection into the muscle. Do not inject it under the skin, into a vein, or give it to a child by mouth. Prolonged use of Acthar Gel may produce cataracts, glaucoma, and secondary ocular infections. Monitor for signs and symptoms.

Step-by-step injection training guides

Available in English and Spanish for the parents and caregivers of infants with IS. See available Acthar Gel resources.

Helpful Resources

Download the IS dosing app now

Have the IS Dosing Calculator app ready when you need it.

Acthar Referral Form

Download, complete, and fax the Referral Form to order Acthar Gel for your appropriate patients.

Reimbursement support and financial assistance

Patients can get individualized support from Case Managers at the Acthar Patient Support Team, including help during the insurance approval process and finding financial assistance options.

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